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Characterization of developing proteome during early childhood

ABSTRACT: Children develop rapidly during the first years of life, and understanding the different sources and levels of variation in serum proteome of young children is important when using serum proteins as markers for childhood diseases. We have performed label/free quantitative proteomics for longitudinal serum samples collected from a group of children during the first years of life.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Niina Lietzen

LAB HEAD: Riitta Lahesmaa

PROVIDER: PXD006775 | Pride | 2018-04-18

REPOSITORIES: Pride

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Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.

Lietzén Niina N Cheng Lu L Moulder Robert R Siljander Heli H Laajala Essi E Härkönen Taina T Peet Aleksandr A Vehtari Aki A Tillmann Vallo V Knip Mikael M Lähdesmäki Harri H Lahesmaa Riitta R

Scientific reports 20180412 1

Children develop rapidly during the first years of life, and understanding the sources and associated levels of variation in the serum proteome is important when using serum proteins as markers for childhood diseases. The aim of this study was to establish a reference model for the evolution of a healthy serum proteome during early childhood. Label-free quantitative proteomics analyses were performed for 103 longitudinal serum samples collected from 15 children at birth and between the ages of 3 ...[more]

PMID: 29650987

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