Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA326952
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Epithelial Cell, Cell Culture
DISEASE(S): Multiple Myeloma
SUBMITTER: Dominik Cysewski
LAB HEAD: Andrzej Dziembowski
PROVIDER: PXD006790 | Pride | 2018-03-09
REPOSITORIES: Pride
Mroczek Seweryn S Chlebowska Justyna J Kuliński Tomasz M TM Gewartowska Olga O Gruchota Jakub J Cysewski Dominik D Liudkovska Vladyslava V Borsuk Ewa E Nowis Dominika D Dziembowski Andrzej A
Nature communications 20170920 1
FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma cell lines, but not its catalytically-inactive mutant, leads to broad polyadenylation and stabilization of mRNAs strongly enriched with those encoding endoplasmic reticulum-targeted p ...[more]