PDGF-hSyn Synaptosomes (vGlut FASS) nanoLC-MS/MS

ABSTRACT: This project studies the differential abundance of proteins at excitatory synapses of PDGF-hSyn mice (Masliah et al., 2000, Science), which are a model for Parkinson’s disease/dementia with Lewy bodies. The mice overexpress human alpha synuclein under the human PDGF promoter. Synapses were purified from animals expressing fluorescently tagged vGlut1 (vGlut1-Venus) using fluorescence activated synapse sorting (FASS; cf. Biesemann et al., 2014, EMBO J).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Mario Dorostkar  

LAB HEAD: Mario Dorostkar

PROVIDER: PXD006812 | Pride | 2019-09-02

REPOSITORIES: Pride