Proteomics

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Modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles


ABSTRACT: ZnO nanoparticles (NPs) are widely used in industrial and consumer products. Thus, understanding their interaction with biological systems is the key for their safe application. The aim of present study was to evaluate the toxicological effects on the intestine of common carp, Cyprinus carpio, after dietary exposure to ZnO NPs. To assess the toxicity of ZnO NPs and of their toxic mechanism to gastrointestinal tract, we applied label free protein quantification on carp intestine considering the fact that fish are on the top of food chain in aquatic ecosystems. Even though carp and zebrafish do not have five intestinal segments like mammals (Brugman, 2016), previous studies have revealed that intestinal anatomy and architecture in cyprinid teleost fish is closely related to mammals with functional homology (Curry, 1939). Therefore, the findings can also provide beneficial information to understand the mechanisms underlying NPs toxicity in mammals.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Cyprinus Carpio (common Carp)

TISSUE(S): Intestine

SUBMITTER: Latifeh Chupani  

LAB HEAD: Dr. Nico Jehmlich

PROVIDER: PXD006867 | Pride | 2017-09-25

REPOSITORIES: Pride

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Insight into the modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles.

Chupani Latifeh L   Niksirat Hamid H   Lünsmann Vanessa V   Haange Sven-Bastiaan SB   von Bergen Martin M   Jehmlich Nico N   Zuskova Eliska E  

The Science of the total environment 20170926


ZnO nanoparticles (NPs) are widely used in industrial and consumer products. Therefore understanding their interaction with biological systems is key to their safe application. Proteomics was applied to assess the sub-lethal effects of dietary ZnO NPs on two parts of carp intestine, the intestinal folds and the muscular parts. A commercial carp feed containing 500mgkg<sup>-1</sup> of ZnO NPs was fed to fish for six weeks. The abundances of 32 proteins in the treated intestinal folds were signifi  ...[more]

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