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Whole proteome and phosphoproteome profiling of CD8+ and CD8- dendritic cells

ABSTRACT: Analyzing and comparing proteome and phosphoproteome profiling between CD8+ DC and CD8- DC not only will be very helpful to understand the molecular mechanisms regulating CD8+/- DC differentiation and function but also can screen CD8+ or CD8- DC specific regulatory pathways or molecules.

OTHER RELATED OMICS DATASETS IN: PRJNA392945

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Dendritic Cell

SUBMITTER: Yuxin Li

LAB HEAD: Junmin Peng

PROVIDER: PXD006875 | Pride | 2018-06-11

REPOSITORIES: Pride

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Publications

Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.

Du Xingrong X Wen Jing J Wang Yanyan Y Karmaus Peer W F PWF Khatamian Alireza A Tan Haiyan H Li Yuxin Y Guy Cliff C Nguyen Thanh-Long M TM Dhungana Yogesh Y Neale Geoffrey G Peng Junmin J Yu Jiyang J Chi Hongbo H

Nature 20180530 7708

Dendritic cells orchestrate the crosstalk between innate and adaptive immunity. CD8α+ dendritic cells present antigens to CD8+ T cells and elicit cytotoxic T cell responses to viruses, bacteria and tumours 1 . Although lineage-specific transcriptional regulators of CD8α+ dendritic cell development have been identified 2 , the molecular pathways that selectively orchestrate CD8α+ dendritic cell function remain elusive. Moreover, me ...[more]

PMID: 29849151

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