Proteomics

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Proteomics study of skin tissues from RDEB cSCC, low-risk cSCC and metastasizing cSCC

ABSTRACT: Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in recessive dystrophic epidermolysis bullosa (RDEB) patients but remains poorly studied on a proteomic level. We aim to characterize the RDEB-SCC proteome by comparing it to the proteomes of UV-light induced cSCC of non-aggressive and aggressive behavior with which RDEB cSCC share either the well-differentiated morphology or the aggressive behavior, respectively. We applied a direct trypsinization protocol using an acid labile surfactant and label-free quantitation to study formalin-fixed, paraffin-embedded tissues from patients with RDEB cSCC (n=6), low-risk cSCC (n=5) and metastasizing cSCC (n=13) by liquid chromatography tandem-mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

DISEASE(S): Skin Squamous Cell Carcinoma

SUBMITTER: Melanie Christine Föll  

LAB HEAD: Oliver Schilling

PROVIDER: PXD006914 | Pride | 2017-11-27

REPOSITORIES: Pride

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Publications

Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.

Föll Melanie C MC   Fahrner Matthias M   Gretzmeier Christine C   Thoma Käthe K   Biniossek Martin L ML   Kiritsi Dimitra D   Meiss Frank F   Schilling Oliver O   Nyström Alexander A   Kern Johannes S JS  

Matrix biology : journal of the International Society for Matrix Biology 20171120

In this study we used a genetic extracellular matrix (ECM) disease to identify mechanisms associated with aggressive behavior of cutaneous squamous cell carcinoma (cSCC). cSCC is one of the most common malignancies and usually has a good prognosis. However, some cSCCs recur or metastasize and cause significant morbidity and mortality. Known factors that are associated with aggressiveness of cSCCs include tumor grading, size, localization and microinvasive behavior. To investigate molecular mecha  ...[more]

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