Dataset Information
Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S-transferases
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Matthew Monroe
LAB HEAD: Aaron Wright
PROVIDER: PXD006920 | Pride | 2018-10-22
REPOSITORIES: Pride
Publications
Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S-Transferases.
Journal of the American Chemical Society 20171101 45
Glutathione S-transferases (GSTs) comprise a diverse family of phase II drug metabolizing enzymes whose shared function is the conjugation of reduced glutathione (GSH) to endo- and xenobiotics. Although the conglomerate activity of these enzymes can be measured, the isoform-specific contribution to the metabolism of xenobiotics in complex biological samples has not been possible. We have developed two activity-based probes (ABPs) that characterize active GSTs in mammalian tissues. The GST active ...[more]
