Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, T Cell
DISEASE(S): Meningioma
SUBMITTER: Michal Bassani-Sternberg
LAB HEAD: Michal Bassani-Sternberg
PROVIDER: PXD006939 | Pride | 2017-12-15
REPOSITORIES: Pride
Chong Chloe C Marino Fabio F Pak HuiSong H Racle Julien J Daniel Roy T RT Müller Markus M Gfeller David D Coukos George G Bassani-Sternberg Michal M
Molecular & cellular proteomics : MCP 20171214 3
Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II peptides presented to T-cells is crucial for designing innovative therapeutics against cancer and other diseases. However methodologies for their purification for mass-spectrometry analysis have been a major limitation. We designed a novel high-throughput, reproducible and sensitive method for sequential immuno-affinity purification of HLA-I and -II peptides from up to 96 samples in a plate format, suitable for bot ...[more]