Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
DISEASE(S): Rett Syndrome
SUBMITTER: Veronica Dumit
LAB HEAD: Veronica Dumit
PROVIDER: PXD007040 | Pride | 2019-11-11
REPOSITORIES: Pride
Weise Stefan C SC Arumugam Ganeshkumar G Villarreal Alejandro A Videm Pavankumar P Heidrich Stefanie S Nebel Nils N Dumit VerĂ³nica I VI Sananbenesi Farahnaz F Reimann Viktoria V Craske Madeline M Schilling Oliver O Hess Wolfgang R WR Fischer Andre A Backofen Rolf R Vogel Tanja T
Molecular neurobiology 20181211 7
Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between progenitor proliferation and neuronal differentiation. Using genome-wide small RNA sequencing and quantitative proteomics, we identified that FOXG1 affects the biogenesis of miR200b/a/4 ...[more]