Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers

ABSTRACT: Meningiomas are common brain tumours arising from meningeal tissue. Despite the majority of them displaying benign features, they can cause mild to severe morbidity. The current main therapeutic approach is complete tumour resection commonly with adjunct radiation therapy. However, tumour location can hamper complete resection and chemotherapies are ineffective. In this study we aim to elucidate dysregulated pathways in meningioma pathogenesis and identify novel molecular targets by deciphering the proteome and phosphoproteome of different grades of meningiomas. Tumour lysates were collected from grade I, II and III frozemeningioma specimens and three normal healthy human meninges.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Meningioma

SUBMITTER: Jemma Dunn  

LAB HEAD: Clemens Oliver Hanemann

PROVIDER: PXD007044 | Pride | 2019-01-07

REPOSITORIES: Pride