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Human A549 CD38, part 2 - Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition

ABSTRACT: SILAC-Labeled proteomic analysis of A549 CD38 human lung cancer cell

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: weixuan wang

LAB HEAD: haiteng deng

PROVIDER: PXD007123 | Pride | 2018-07-11

REPOSITORIES: Pride

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Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition.

Wang Weixuan W Hu Yadong Y Yang Changmei C Zhu Songbiao S Wang Xiaofei X Zhang Zhenyu Z Deng Haiteng H

Molecular & cellular proteomics : MCP 20180706 10

Nicotinamide adenine dinucleotide (NAD) plays an essential role in all aspects of human life. NAD levels decrease as humans age, and supplementation with NAD precursors plays a protective role against aging and associated disease. Less is known about the effects of decreased NAD on cellular processes, which is the basis for understanding the relationship between cellular NAD levels and aging-associated disease. In the present study, cellular NAD levels were decreased by overexpression of CD38, a ...[more]

PMID: 29980616

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