Proteomics

Dataset Information

Quantitative proteomics of barrier-deficient mouse epidermis in response to environmental humidity

ABSTRACT: Low environmental humidity aggravates symptoms of inflammatory skin diseases, e.g. of Atopic Dermatitis (AD). Using mice that develop AD-like symptoms, we show that an increase in environmental humidity rapidly rescues their cutaneous inflammation and associated epidermal abnormalities. Quantitative proteomics analysis of epidermal lysates of mice kept at low or high humidity identified novel humidity-regulated proteins, including Clca2/Clca3a2, a protein with previously unknown function in the skin.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

SUBMITTER: Ulrich auf dem Keller  

LAB HEAD: Sabine Werner

PROVIDER: PXD007124 | Pride | 2018-05-14

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20140620_FGFRxHumidity_GoldenLane_30percent_coisolation.pdResult Other
20140620_FGFRxHumidity_GoldenLane_30percent_coisolation.pdResultView Other
20140620_humid_fract_setA_03_B2.raw Raw
20140620_humid_fract_setA_04_B3.raw Raw
20140620_humid_fract_setA_05_B4.raw Raw
Items per page:
1 - 5 of 26
altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets