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Tasmanian Devil Facial Tumour Disease - Imiquimod treatment of DFT1 cells

ABSTRACT: A Tasmanian Devil Facial Tumour Disease (DFTD) tumor cell line was treated with the drug Imiquimod

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Sarcophilus Harrisii

TISSUE(S): Cell Culture

SUBMITTER: Richard Wilson

LAB HEAD: Richard Wilson

PROVIDER: PXD007135 | Pride | 2018-04-12

REPOSITORIES: Pride

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Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells.

Patchett Amanda L AL Wilson Richard R Charlesworth Jac C JC Corcoran Lynn M LM Papenfuss Anthony T AT Lyons Bruce A BA Woods Gregory M GM Tovar Cesar C

Oncotarget 20180323 22

As a topical cancer immunotherapy, the toll-like receptor 7 ligand imiquimod activates tumor regression via stimulation of immune cell infiltration and cytotoxic responses. Imiquimod also exerts direct pro-apoptotic effects on tumor cells <i>in vitro</i>, but a role for these effects in imiquimod-induced tumor regression remains undefined. We previously demonstrated that cell lines derived from devil facial tumor disease (DFTD), a transmissible cancer threatening the survival of the Tasmanian de ...[more]

PMID: 29662615

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