Ceritinib Functional Proteomics
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
SUBMITTER: 
Brent Kuenzi
LAB HEAD: Uwe Rix
PROVIDER: PXD007137 | Pride | 2018-01-12
REPOSITORIES: Pride
Publications
Polypharmacology-based ceritinib repurposing using integrated functional proteomics.
Kuenzi Brent M BM Remsing Rix Lily L LL Stewart Paul A PA Fang Bin B Kinose Fumi F Bryant Annamarie T AT Boyle Theresa A TA Koomen John M JM Haura Eric B EB Rix Uwe U
Nature chemical biology 20171009 12
Targeted drugs are effective when they directly inhibit strong disease drivers, but only a small fraction of diseases feature defined actionable drivers. Alternatively, network-based approaches can uncover new therapeutic opportunities. Applying an integrated phenotypic screening, chemical and phosphoproteomics strategy, here we describe the anaplastic lymphoma kinase (ALK) inhibitor ceritinib as having activity across several ALK-negative lung cancer cell lines and identify new targets and netw ...[more]
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