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Targeted proteomics analysis of single glomeruli in Doxorubicin-induced FSGS

ABSTRACT: We analyzed the proteome of single glomeruli from mouse kidney with Doxorubicin-induced FSGS. We analyzed the proteomes by PRM.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Markus Rinschen

LAB HEAD: Markus Rinschen

PROVIDER: PXD007144 | Pride | 2018-06-28

REPOSITORIES: Pride

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Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne Martin M Frese Christian K CK Grahammer Florian F Dafinger Claudia C Ciarimboli Giuliano G Butt Linus L Binz Julia J Hackl Matthias J MJ Rahmatollahi Mahdieh M Kann Martin M Schneider Simon S Altintas Mehmet M MM Schermer Bernhard B Reinheckel Thomas T Göbel Heike H Reiser Jochen J Huber Tobias B TB Kramann Rafael R Seeger-Nukpezah Tamina T Liebau Max C MC Beck Bodo B BB Benzing Thomas T Beyer Andreas A Rinschen Markus M MM

Kidney international 20180309 6

In diseases of many parenchymatous organs, heterogeneous deterioration of individual functional units determines the clinical prognosis. However, the molecular characterization at the level of such individual subunits remains a technological challenge that needs to be addressed in order to better understand pathological mechanisms. Proteinuric glomerular kidney diseases are frequent and assorted diseases affecting a fraction of glomeruli and their draining tubules to variable extents, and for wh ...[more]

PMID: 29530281

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