Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cd4-positive Helper T Cell, Helper T-lymphocyte
DISEASE(S): Type 1 Diabetes Mellitus
SUBMITTER: Marlen Lepper
LAB HEAD: Stefanie M. Hauck
PROVIDER: PXD007184 | Pride | 2017-11-30
REPOSITORIES: Pride
Journal of proteome research 20171213 1
The pathophysiology underlying the autoimmune disease type 1 diabetes (T1D) is poorly understood. Obtaining an accurate proteomic profile of the T helper cell population is essential for understanding the pathogenesis of T1D. Here, we performed in-depth proteomic profiling of peripheral CD4+ T cells in a pediatric cohort to identify cellular signatures associated with the onset of T1D. Using only 250 000 CD4+ T cells per patient, isolated from biobanked PBMC samples, we identified nearly 6000 pr ...[more]