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Proteomic analysis of germinal vesicles from preantral vs antral follicles in the domestic cat model

ABSTRACT: The domestic cat germinal vesicle (GV), which is physiologically similar to the human GV, gains the intrinsic ability to resume meiosis and support early embryo development during the pre-antral-to-antral follicle transition. However, little is known about nuclear proteins that contribute to this developmental process. We performed proteomic analysis of GVs identified candidate proteins for oocyte competence acquisition.

INSTRUMENT(S): LTQ

ORGANISM(S): Felis Catus (cat) (felis Silvestris Catus)

TISSUE(S): Oocyte

SUBMITTER: Pei-Chih Lee

LAB HEAD: Pierre Comizzoli

PROVIDER: PXD007211 | Pride | 2017-11-14

REPOSITORIES: Pride

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Proteomic analysis of germinal vesicles in the domestic cat model reveals candidate nuclear proteins involved in oocyte competence acquisition.

Lee P-C PC Wildt D E DE Comizzoli P P

Molecular human reproduction 20180101 1

<h4>Study question</h4>Do nuclear proteins in the germinal vesicle (GV) contribute to oocyte competence acquisition during folliculogenesis?<h4>Summary answer</h4>Proteomic analysis of GVs identified candidate proteins for oocyte competence acquisition, including a key RNA processing protein-heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1).<h4>What is known already</h4>The domestic cat GV, which is physiologically similar to the human GV, gains the intrinsic ability to resume meiosis an ...[more]

PMID: 29126204

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