Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Guohong Hu
LAB HEAD: Guohong Hu
PROVIDER: PXD007227 | Pride | 2017-10-04
REPOSITORIES: Pride
Zhuang Xueqian X Zhang Hao H Li Xiaoyan X Li Xiaoxun X Cong Min M Peng Fangli F Yu Jingyi J Zhang Xue X Yang Qifeng Q Hu Guohong G
Nature cell biology 20170911 10
Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and neutrophil recruitment in lung metastases by antagonizing cancer cell non-canonical WNT/PCP-RAC1-JNK signalling. In the lungs, DKK1 also inhibits WNT/Ca<sup>2+</sup>-CaMKII-NF-κB sign ...[more]