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TbSTT3A and TbSTT3B hetero-oligomeric complex

ABSTRACT: Directly address the oligomeric states of T. brucei STT3 subunits

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Trypanosoma Brucei

SUBMITTER: Michele Tinti

LAB HEAD: Michael Ferguson

PROVIDER: PXD007236 | Pride | 2017-09-20

REPOSITORIES: Pride

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Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities.

Jinnelov Anders A Ali Liaqat L Tinti Michele M Güther Maria Lucia S MLS Ferguson Michael A J MAJ

The Journal of biological chemistry 20170919 49

Trypanosoma brucei causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite. These OSTs have different peptide acceptor and lipid-linked oligosaccharide donor specificities, and trypanosomes do not follow many of the canonical rules developed for other eukaryotic N-glycosylation pathways, raising questions as to the basic architecture an ...[more]

PMID: 28928222

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