Effect of rRNA methylation defect on protein composition of human ribosomes

ABSTRACT: Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation is the most abundant rRNA chemical modification, and display a complex pattern in rRNA. We globally challenged rRNA 2'-O-Me by inhibiting the rRNA methyl-transferase fibrillarin (FBL) in human cells. Since FBL participates in rRNA processing, we wonder if FBL knockdown could alter the assembly of ribosomes.

OTHER RELATED OMICS DATASETS IN: PRJNA415055

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fibroblast

SUBMITTER: Yohann Couté  

LAB HEAD: Brun Virginie

PROVIDER: PXD007244 | Pride | 2018-04-09

REPOSITORIES: Pride