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Caloric restriction and rat fecal microbiota

ABSTRACT: Characterization of the fecal metaproteome in rats fed ad libitum or following a caloric restriction diet

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rat Gut Metagenome

TISSUE(S): Feces

SUBMITTER: Alessandro Tanca

LAB HEAD: Sergio Uzzau

PROVIDER: PXD007252 | Pride | 2018-10-08

REPOSITORIES: Pride

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Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota.

Tanca Alessandro A Abbondio Marcello M Palomba Antonio A Fraumene Cristina C Marongiu Fabio F Serra Monica M Pagnozzi Daniela D Laconi Ezio E Uzzau Sergio S

Scientific reports 20181003 1

Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the short- and long-term effects of CR on the rat GM using a metaproteogenomic approach. We show that a switch from ad libitum (AL) low fat diet to CR in young rats is able to induce rapid and deep changes in their GM metaproteomic profile, related to a reduction o ...[more]

PMID: 30283130

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