Proteomics

Dataset Information

0

Calcium/calmodulin dependent protein kinase kinase 2 (CAMKK2), an alternative to curcumin in head and neck squamous cell carcinoma.


ABSTRACT: Curcumin has been shown to exhibit anti-neoplastic effects. However, due to its poor bioavailability, use of curcumin as an anti-cancer drug is limited. It is thus necessary to identify molecules that could be targeted using anti-cancer agents as alternatives to curcumin. For this, it is important to understand the underlying signaling pathways mediating the anti-neoplastic effects of curcumin. We carried out phosphoproteomic analysis (TiO2-based enrichment of Ser/Thr kinases) of head and neck cancer cell line, CAL27 treated with curcumin to identify curcumin mediated signaling pathways. This resulted in the identification of 5921 phosphopeptides (phosphosite probability≥75%) corresponding 1,878 proteins. Of these, 275 and 335 phosphopeptides corresponding to 183 and 242 proteins (≥2.0-fold) were found to be hyper- and hypo-phosphorylated respectively, in response to curcumin treatment

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oral Epithelium

DISEASE(S): Oral Cavity Cancer

SUBMITTER: Aditi Chatterjee  

LAB HEAD: Aditi Chatterjee

PROVIDER: PXD007256 | Pride | 2022-03-03

REPOSITORIES: Pride

Similar Datasets

2019-12-18 | PXD007785 | Pride
2018-10-24 | PXD002097 | Pride
2016-12-14 | PXD003108 | Pride
2017-08-11 | PXD004868 | Pride
2022-10-13 | PXD007769 | Pride
2021-09-07 | PXD007814 | Pride
2018-01-08 | PXD003092 | Pride
2016-05-25 | PXD001812 | Pride
2010-04-06 | E-GEOD-21182 | biostudies-arrayexpress
2010-04-06 | GSE21182 | GEO