Proteomics,Multiomics

Dataset Information

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Human hepatic stellate cell-derived extracellular vesicles LC-MSMS


ABSTRACT: Activation and migration of hepatic stellate cells (HSCs) followed by matrix deposition are characteristics of liver fibrosis. Several studies have shown the importance of hepatocyte and endothelial cell-derived extracellular vesicles (EVs) in liver pathobiology. However, less is known about the role of HSC-derived EVs in liver diseases. In this study, we investigated the molecules released through HSC-derived EVs and whether these can promote fibrosis.

OTHER RELATED OMICS DATASETS IN: GSE140110

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatic Stellate Cell, Liver

DISEASE(S): Hepatic Fibrosis

SUBMITTER: Enis Kostallari  

LAB HEAD: Vijay H. Shah, M.D.

PROVIDER: PXD007258 | Pride | 2018-10-18

REPOSITORIES: Pride

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Publications

Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.

Kostallari Enis E   Hirsova Petra P   Prasnicka Alena A   Verma Vikas K VK   Yaqoob Usman U   Wongjarupong Nicha N   Roberts Lewis R LR   Shah Vijay H VH  

Hepatology (Baltimore, Md.) 20180510 1


Liver fibrosis is characterized by the activation and migration of hepatic stellate cells (HSCs), followed by matrix deposition. Recently, several studies have shown the importance of extracellular vesicles (EVs) derived from liver cells, such as hepatocytes and endothelial cells, in liver pathobiology. While most of the studies describe how liver cells modulate HSC behavior, an important gap exists in the understanding of HSC-derived signals and more specifically HSC-derived EVs in liver fibros  ...[more]

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