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Protein data in PHH after VPA-treatment

ABSTRACT: LC-MS/MS protein data of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell, Liver

SUBMITTER: Jarno Wolters

LAB HEAD: Jarno Wolters

PROVIDER: PXD007538 | Pride | 2018-02-27

REPOSITORIES: Pride

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Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

Wolters Jarno E J JEJ van Breda Simone G J SGJ Grossmann Jonas J Fortes Claudia C Caiment Florian F Kleinjans Jos C S JCS

Toxicology letters 20180306

We performed a multiple 'omics study by integrating data on epigenomic, transcriptomic, and proteomic perturbations associated with mitochondrial dysfunction in primary human hepatocytes caused by the liver toxicant valproic acid (VPA), to deeper understand downstream events following epigenetic alterations in the mitochondrial genome. Furthermore, we investigated persistence of cross-omics changes after terminating drug treatment. Upon transient methylation changes of mitochondrial genes during ...[more]

PMID: 29501571

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