Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Macrophage
SUBMITTER: Nicolas Nalpas
LAB HEAD: Alexander N.R. Weber
PROVIDER: PXD007542 | Pride | 2019-11-12
REPOSITORIES: Pride
El Maadidi Souhayla S Weber Alexander N R ANR Motshwene Precious P Schüssler Jan Moritz JM Backes Daniel D Dickhöfer Sabine S Wang Hui H Liu Xiao X Garcia Magno Delmiro MD Taumer Christoph C Soufi Boumediene B Wolz Olaf-Oliver OO Klimosch Sascha N SN Franz-Wachtel Mirita M Macek Boris B Gay Nicholas J NJ
Scientific reports 20190911 1
Toll-like receptors (TLRs) are important sentinels of bacterial and viral infection and thus fulfil a critical sensory role in innate immunity. Polo-like kinases (PLKs), a five membered family of Ser/Thr protein kinases, have long been studied for their role in mitosis and thus represent attractive therapeutic targets in cancer therapy. Recently, PLKs were implicated in TLR signaling in mice but the role of PLKs in TLR signaling in untransformed primary immune cells has not been addressed, even ...[more]