Proteomics

Dataset Information

0

Novel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling.


ABSTRACT: This project contains the proteomics data for the manuscript "Novel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling." by Au et al.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Aorta Thoracica

DISEASE(S): Cardiovascular System Disease

SUBMITTER: William Fondrie  

LAB HEAD: Dudley K Strickland

PROVIDER: PXD007544 | Pride | 2018-10-22

REPOSITORIES: Pride

altmetric image

Publications

LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca<sup>2+</sup> Signaling and Expression of Cytoskeleton-Related Proteins.

Au Dianaly T DT   Ying Zhekang Z   Hernández-Ochoa Erick O EO   Fondrie William E WE   Hampton Brian B   Migliorini Mary M   Galisteo Rebeca R   Schneider Martin F MF   Daugherty Alan A   Rateri Debra L DL   Strickland Dudley K DK   Muratoglu Selen C SC  

Arteriosclerosis, thrombosis, and vascular biology 20181101 11


Objective- Mutations affecting contractile-related proteins in the ECM (extracellular matrix), microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We reported previously that the LRP1 (low-density lipoprotein receptor-related protein 1) maintains vessel wall integrity, and smLRP1<sup>-/-</sup> mice exhibited aortic dilatation. The current study focused on defining the mechanisms by which LRP1 regulates vessel wall function and integrity. Approach and Results- Iso  ...[more]

Similar Datasets

| E-GEOD-7281 | biostudies-arrayexpress
| E-MTAB-11863 | biostudies-arrayexpress
| E-GEOD-13835 | biostudies-arrayexpress
| E-MTAB-4841 | biostudies-arrayexpress
2022-11-15 | PXD031271 | Pride
| E-GEOD-13865 | biostudies-arrayexpress
| E-MTAB-1930 | biostudies-arrayexpress
| E-GEOD-67077 | biostudies-arrayexpress
| E-GEOD-6599 | biostudies-arrayexpress
| E-MTAB-12019 | biostudies-arrayexpress