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Plasmodium falciparum PHIL1 LC-MS/MS

ABSTRACT: Plasmodium falciparum sexual-stage parasites expressing an epitope-tagged PHIL1 protein were analysed by co-IP and subsequent LC-MS/MS as

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Emma McHugh

LAB HEAD: Leann Tilley

PROVIDER: PXD007564 | Pride | 2017-09-28

REPOSITORIES: Pride

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Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development.

Parkyn Schneider Molly M Liu Boyin B Glock Philipp P Suttie Annika A McHugh Emma E Andrew Dean D Batinovic Steven S Williamson Nicholas N Hanssen Eric E McMillan Paul P Hliscs Marion M Tilley Leann L Dixon Matthew W A MWA

PLoS pathogens 20171006 10

Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the human pathogen, Plasmodium falciparum, adopt a crescent shape. Their dramatic morphogenesis is driven by the assembly of a network of microtubules and an underpinning inner membrane complex (IMC). Using super-resolution optical and electron microscopies we define the ultrastructure of the IMC at different stages of gametocyte development. We characterize two new protein ...[more]

PMID: 28985225

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