PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MTBLS533
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: 
Fengfei Ma
LAB HEAD: Lingjun Li
PROVIDER: PXD007671 | Pride | 2018-10-24
REPOSITORIES: Pride
Publications
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Liu Fabao F Ma Fengfei F Wang Yuyuan Y Hao Ling L Zeng Hao H Jia Chenxi C Wang Yidan Y Liu Peng P Ong Irene M IM Li Baobin B Chen Guojun G Jiang Jiaoyang J Gong Shaoqin S Li Lingjun L Xu Wei W
Nature cell biology 20171023 11
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of metabolism from oxidative phosphorylation to aerobic glycolysis in breast cancer cells. Oxidative phosphorylation depends on mitochondrial calcium concentration, which becomes critical for cancer cell su ...[more]
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