Proteomics

Dataset Information

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Francisella tularensis DsbA mutant MS/SILAC analysis


ABSTRACT: Comparison of enriched membrane fractions of Francisella tularensis subsp. holarctica strain FSC200 and its DsbA mutant by SILAC analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Francisella Tularensis Subsp. Holarctica Fsc200

DISEASE(S): Tularemia

SUBMITTER: Jana Klimentova  

LAB HEAD: Jiri Stulik

PROVIDER: PXD007682 | Pride | 2018-01-15

REPOSITORIES: Pride

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Publications

The Multiple Localized Glyceraldehyde-3-Phosphate Dehydrogenase Contributes to the Attenuation of the <i>Francisella tularensis dsbA</i> Deletion Mutant.

Pavkova Ivona I   Kopeckova Monika M   Klimentova Jana J   Schmidt Monika M   Sheshko Valeria V   Sobol Margarita M   Zakova Jitka J   Hozak Pavel P   Stulik Jiri J  

Frontiers in cellular and infection microbiology 20171211


The DsbA homolog of <i>Francisella tularensis</i> was previously demonstrated to be required for intracellular replication and animal death. Disruption of the <i>dsbA</i> gene leads to a pleiotropic phenotype that could indirectly affect a number of different cellular pathways. To reveal the broad effects of DsbA, we compared fractions enriched in membrane proteins of the wild-type FSC200 strain with the <i>dsbA</i> deletion strain using a SILAC-based quantitative proteomic analysis. This analys  ...[more]

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