Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Francisella Tularensis Subsp. Holarctica Fsc200
DISEASE(S): Tularemia
SUBMITTER: Jana Klimentova
LAB HEAD: Jiri Stulik
PROVIDER: PXD007682 | Pride | 2018-01-15
REPOSITORIES: Pride
Pavkova Ivona I Kopeckova Monika M Klimentova Jana J Schmidt Monika M Sheshko Valeria V Sobol Margarita M Zakova Jitka J Hozak Pavel P Stulik Jiri J
Frontiers in cellular and infection microbiology 20171211
The DsbA homolog of <i>Francisella tularensis</i> was previously demonstrated to be required for intracellular replication and animal death. Disruption of the <i>dsbA</i> gene leads to a pleiotropic phenotype that could indirectly affect a number of different cellular pathways. To reveal the broad effects of DsbA, we compared fractions enriched in membrane proteins of the wild-type FSC200 strain with the <i>dsbA</i> deletion strain using a SILAC-based quantitative proteomic analysis. This analys ...[more]