Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo sapiens
TISSUE(S): Blood
DISEASE(S): Not Available
SUBMITTER: Maartje van den Biggelaar
LAB HEAD: Maartje van den Biggelaar
PROVIDER: PXD007744 | Pride | 2018-05-18
REPOSITORIES: pride
Cuadrado Eloy E van den Biggelaar Maartje M de Kivit Sander S Chen Yi-Yen YY Slot Manon M Doubal Ihsane I Meijer Alexander A van Lier Rene A W RAW Borst Jannie J Amsen Derk D
Immunity 20180508 5
To obtain a molecular definition of regulatory T (Treg) cell identity, we performed proteomics and transcriptomics on various populations of human regulatory and conventional CD4+ T (Tconv) cells. A protein expression signature was identified that defines all Treg cells, and another signature that defines effector Treg cells. These signatures could not be extrapolated from transcriptome data. Unique cell-biological and metabolic features in Treg cells were defined, as well as specific adaptation ...[more]