Proteomics

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Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis

ABSTRACT: Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) arewidely used forbovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPDcan give false-positive tuberculosis results because of sequence homologybetween Mycobacterium bovis andM. avium proteins. Here we used proteomics to characterisebPPD, aPPD and an immunopurifiedsubcomplexfrombPPD called P22.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mycobacterium Bovis An5 Mycobacterium Avium Subsp. Avium Atcc 25291

DISEASE(S): Tuberculosis

SUBMITTER: Sergio Ciordia  

LAB HEAD: Mercedes Domínguez

PROVIDER: PXD007766 | Pride | 2018-11-22

REPOSITORIES: Pride

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Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis.

Infantes-Lorenzo José Antonio JA   Moreno Inmaculada I   Risalde María de Los Ángeles MLÁ   Roy Álvaro Á   Villar Margarita M   Romero Beatriz B   Ibarrola Nieves N   de la Fuente José J   Puentes Eugenia E   de Juan Lucía L   Gortázar Christian C   Bezos Javier J   Domínguez Lucas L   Domínguez Mercedes M  

Clinical proteomics 20171102

<h4>Background</h4>Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPD can give false-positive tuberculosis results because of sequence homology between <i>Mycobacterium bovis</i> (<i>M. bovis</i>) and <i>M. avium</i> proteins. Thus, the objective of this study was to  ...[more]

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