Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Oral Epithelium
SUBMITTER: Harsha Gowda
LAB HEAD: Harsha Gowda
PROVIDER: PXD007768 | Pride | 2019-12-18
REPOSITORIES: Pride
Jain Ankit P AP Patel Krishna K Pinto Sneha S Radhakrishnan Aneesha A Nanjappa Vishalakshi V Kumar Manish M Raja Remya R Patil Arun H AH Kumari Anjali A Manoharan Malini M Karunakaran Coral C Murugan Saktivel S Keshava Prasad T S TS Chang Xiaofei X Mathur Premendu Prakash PP Kumar Prashant P Gupta Ravi R Gupta Rohit R Khanna-Gupta Arati A Sidransky David D Chatterjee Aditi A Gowda Harsha H
Scientific reports 20191211 1
Epidermal growth factor receptor (EGFR) targeted therapies have shown limited efficacy in head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression. Identifying molecular mechanisms associated with acquired resistance to EGFR-TKIs such as erlotinib remains an unmet need and a therapeutic challenge. In this study, we employed an integrated multi-omics approach to delineate mechanisms associated with acquired resistance to erlotinib by carrying out whole exome sequencing, q ...[more]