Effect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line

ABSTRACT: Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 blockade on mouse on MED17.11 cells, as a model of dorsal root ganglia (DRG) sensory neurons, in resting and LPS-stimulated conditions. This analysis completes two previously reported ones, which investigated the effects of mycolactone on the proteome of the mouse MutuDC dendritic cells (Project PXD006103) and human Jurkat T cells (Project PXD002971).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Permanent Cell Line Cell, Cell Culture, Sensory Neuron Of Dorsal Root Ganglion

SUBMITTER: Jean-David Morel  

LAB HEAD: Caroline Demangel

PROVIDER: PXD007770 | Pride | 2018-06-26

REPOSITORIES: Pride