Proteomics

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Candida albicans proteomics_Biofilm without treatment

ABSTRACT: The LC-MS/MS approach was utilized to identify qualitative changes in protein expressed by planktonic and biofilm cells of C. albicans and with Aureobasidin treatment.

INSTRUMENT(S): 6520 Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Candida Albicans (yeast)

SUBMITTER: Mun Fai Loke  

LAB HEAD: Loke Mun Fai

PROVIDER: PXD007830 | Pride | 2021-02-25

REPOSITORIES: Pride

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Publications

LC-MS analysis reveals biological and metabolic processes essential for Candida albicans biofilm growth.

Munusamy Komathy K   Loke Mun Fai MF   Vadivelu Jamuna J   Tay Sun Tee ST  

Microbial pathogenesis 20201114

Candidiasis is the most common fungal infection associated with high morbidity and mortality among immunocompromised patients. The ability to form biofilm is essential for Candida albicans pathogenesis and drug resistance. In this study, the planktonic cell and biofilm proteomes of C. albicans SC5314 strain analyzed using Liquid Chromatography-Mass Spectrometry (LC-MS) were compared. In total, 280 and 449 proteins are annotated from the planktonic cell and biofilm proteomes, respectively. The bi  ...[more]

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