Comparative analysis of mRNA degradation and protein degradation in 68 pairs of adjacent prostate tissue samples indicates high stability of proteins

ABSTRACT: Here we investigated the degradation of mRNA and protein in 68 pairs of adjacent prostate tissue samples using RNA-seq and pressure cycling technology (PCT) coupled with SWATH mass spectrometry and developed a score, the Proteome Integrity Number (PIN), to quantify the extent of protein degradation in the samples.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Adenocarcinoma Cell, Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Wenguang Shao  

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD007841 | Pride | 2019-06-12

REPOSITORIES: Pride