Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Paul Boersema
LAB HEAD: Paola Picotti
PROVIDER: PXD007873 | Pride | 2018-10-10
REPOSITORIES: Pride
Laferrière Florent F Maniecka Zuzanna Z Pérez-Berlanga Manuela M Hruska-Plochan Marian M Gilhespy Larissa L Hock Eva-Maria EM Wagner Ulrich U Afroz Tariq T Boersema Paul J PJ Barmettler Gery G Foti Sandrine C SC Asi Yasmine T YT Isaacs Adrian M AM Al-Amoudi Ashraf A Lewis Amanda A Stahlberg Henning H Ravits John J De Giorgi Francesca F Ichas François F Bezard Erwan E Picotti Paola P Lashley Tammaryn T Polymenidou Magdalini M
Nature neuroscience 20181217 1
Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases into at least four subtypes, which are correlated with clinical presentations and genetic causes. To understand the molecular basis of this heterogeneity, we developed SarkoSpin, a ne ...[more]