Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Macrophage
SUBMITTER: Monika Zareba-Koziol
LAB HEAD: Katarzyna Kwiatkowska
PROVIDER: PXD007918 | Pride | 2017-12-15
REPOSITORIES: Pride
Sobocińska Justyna J Roszczenko-Jasińska Paula P Zaręba-Kozioł Monika M Hromada-Judycka Aneta A Matveichuk Orest V OV Traczyk Gabriela G Łukasiuk Katarzyna K Kwiatkowska Katarzyna K
Molecular & cellular proteomics : MCP 20171207 2
Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria that induces strong proinflammatory reactions of mammals. These processes are triggered upon sequential binding of LPS to CD14, a GPI-linked plasma membrane raft protein, and to the TLR4/MD2 receptor complex. We have found earlier that upon LPS binding, CD14 triggers generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P<sub>2</sub>], a lipid controlling subsequent proinflammatory cytokine production. ...[more]