Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Tommy Hofmann
LAB HEAD: Carla Schmidt
PROVIDER: PXD007928 | Pride | 2017-11-07
REPOSITORIES: Pride
Blees Andreas A Januliene Dovile D Hofmann Tommy T Koller Nicole N Schmidt Carla C Trowitzsch Simon S Moeller Arne A Tampé Robert R
Nature 20171106 7681
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and editing of major histocompatibility complex class I (MHC-I) molecules. After final proofreading in the PLC, stable peptide-MHC-I complexes are released to the cell surface to evoke a T-cell response against infected or malignant cells ...[more]