Proteomics

Dataset Information

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Proteomic analysis of rat glomeruli from the salt sensitive Dahl rat


ABSTRACT: We analyzed the glomerular proteome of hypertensive rats developing FSGS.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Kidney

SUBMITTER: Markus Rinschen  

LAB HEAD: Markus Rinschen

PROVIDER: PXD007940 | Pride | 2019-11-20

REPOSITORIES: Pride

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Publications


Hypertension is a persistent epidemic across the developed world that is closely associated with kidney disease. Here, we applied a metabolomic, phosphoproteomic, and proteomic strategy to analyze the effect of hypertensive insults on kidneys. Our data revealed the metabolic aspects of hypertension-induced glomerular sclerosis, including lipid breakdown at early disease stages and activation of anaplerotic pathways to regenerate energy equivalents to counter stress. For example, branched-chain a  ...[more]

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