Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA317750
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Claudio Ponte de Albuquerque
LAB HEAD: Bing Ren
PROVIDER: PXD007942 | Pride | 2018-10-23
REPOSITORIES: Pride
Local Andrea A Huang Hui H Albuquerque Claudio P CP Singh Namit N Lee Ah Young AY Wang Wei W Wang Chaochen C Hsia Judy E JE Shiau Andrew K AK Ge Kai K Corbett Kevin D KD Wang Dong D Zhou Huilin H Ren Bing B
Nature genetics 20171218 1
Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific manner. Whether and how this histone modification regulates enhancer-dependent transcription programs in mammals is unclear. In this study, we conducted SILAC mass spectrometry experiments with mononucleosomes and identified multiple H3K4me1- ...[more]