Hydroxyapatite-binding plasma proteins in Age-related macular degenaration
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
SUBMITTER: 
Silvia Synowsky
LAB HEAD: Alan J. Stewart
PROVIDER: PXD007944 | Pride | 2018-03-28
REPOSITORIES: Pride
Publications
Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration.
Arya Swati S Emri Eszter E Synowsky Silvia A SA Shirran Sally L SL Barzegar-Befroei Neda N Peto Tunde T Botting Catherine H CH Lengyel Imre I Stewart Alan J AJ
Experimental eye research 20180324
Age-related macular degeneration (AMD) is associated with the formation of sub-retinal pigment epithelial (RPE) deposits that block circulatory exchange with the retina. The factors that contribute to deposit formation are not well understood. Recently, we identified the presence of spherular hydroxyapatite (HAP) structures within sub-RPE deposits to which several AMD-associated proteins were bound. This suggested that protein binding to HAP represents a potential mechanism for the retention of ...[more]
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