Hydroxyapatite-binding plasma proteins in Age-related macular degenaration

ABSTRACT: This project identifies and quantitates Hydroxyapatite binding proteins (HAP) in plasma genotyped for complement factor H (CFH) polymorphism in late stage age-related macular degeneration (AMD) patients by sequential window acquisition of all theoretical mass spectra (SWATH). This study provides insights into factors contributing to the formation of sub-retinal pigment epithelial (RPE) deposits and explores the effect of AMD-associated CFH polymorphism on deposit composition.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Silvia Synowsky  

LAB HEAD: Alan J. Stewart

PROVIDER: PXD007944 | Pride | 2018-03-28

REPOSITORIES: Pride