Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE104949
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Cervix Epithelium
SUBMITTER: Gracjan Michlewski
LAB HEAD: Dr. Gracjan Michlewski
PROVIDER: PXD007960 | Pride | 2017-10-19
REPOSITORIES: Pride
BMC biology 20171108 1
<h4>Background</h4>TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain has not been characterized.<h4>Results</h4>Here, we reveal that the RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain, which we postulate to be a novel RNA-binding domain. Using ...[more]