Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Glioblastoma
SUBMITTER: Shinyeong Ju
LAB HEAD: Cheolju Lee
PROVIDER: PXD007969 | Pride | 2018-07-16
REPOSITORIES: Pride
Lim Sungsu S Kim Dohee D Ju Shinyeong S Shin Seulgi S Cho Il-Joo IJ Park Sung-Hye SH Grailhe Regis R Lee Cheolju C Kim Yun Kyung YK
Experimental & molecular medicine 20180406 4
During aggressive tumor growth and migration, glioblastoma cells secrete diverse molecules and adhesion proteins to the extracellular matrix. Yet, the biochemical effects of the glioblastoma secretome in the brain remain largely unknown. Here we show that soluble CD44 secreted from glioblastoma cells induces neuronal degeneration through the activation of tau pathology in the brain. Glioblastoma-xenograft tissues showed a number of degenerating neurons bearing highly phosphorylated tau. Through ...[more]