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Melanoma BRAFV600E induced proteome

ABSTRACT: By analyzing of the changes in proteome mediated by the oncogene BRAFV600E in melanoma cells we provide new insights on the pathways upregulated in these cells and possible new targets for therapy.

OTHER RELATED OMICS DATASETS IN: GSE111891

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

SUBMITTER: Francesca Rapino

LAB HEAD: Francesca Rapino

PROVIDER: PXD008010 | Pride | 2018-06-25

REPOSITORIES: Pride

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Codon-specific translation reprogramming promotes resistance to targeted therapy.

Rapino Francesca F Delaunay Sylvain S Rambow Florian F Zhou Zhaoli Z Tharun Lars L De Tullio Pascal P Sin Olga O Shostak Kateryna K Schmitz Sebastian S Piepers Jolanda J Ghesquière Bart B Karim Latifa L Charloteaux Benoit B Jamart Diane D Florin Alexandra A Lambert Charles C Rorive Andrée A Jerusalem Guy G Leucci Eleonora E Dewaele Michael M Vooijs Marc M Leidel Sebastian A SA Georges Michel M Voz Marianne M Peers Bernard B Büttner Reinhard R Marine Jean-Christophe JC Chariot Alain A Close Pierre P

Nature 20180620 7711

Reprogramming of mRNA translation has a key role in cancer development and drug resistance 1 . However, the molecular mechanisms that are involved in this process remain poorly understood. Wobble tRNA modifications are required for specific codon decoding during translation2,3. Here we show, in humans, that the enzymes that catalyse modifications of wobble uridine 34 (U34) tRNA (U34 enzymes) are key players of the protein synthesis rewiring that is ind ...[more]

PMID: 29925953

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