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Olfactory proteomics in Parkinson disease

ABSTRACT: Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies (LTS) such as Parkinson´s disease (PD). However, the underlying molecular mechanisms associated to smell impairment is poorly understood. To reveal the missing links in the biochemical understanding of olfactory dysfunction in PD, we have applied mass spectrometry-based proteomics in postmortem olfactory bulbs (OBs) dissected from parkinsonian subjects with different LTS staging respect to elderly controls (n= 24, mean age 79 years).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Parkinson's Disease

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD008036 | Pride | 2018-10-24

REPOSITORIES: Pride

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Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling.

Lachén-Montes Mercedes M González-Morales Andrea A Iloro Ibon I Elortza Felix F Ferrer Isidre I Gveric Djordje D Fernández-Irigoyen Joaquín J Santamaría Enrique E

Neurobiology of aging 20180925

Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies (LTSs) such as Parkinson's disease (PD). However, the underlying molecular mechanisms associated to smell impairment are poorly understood. Applying mass spectrometry-based quantitative proteomics in postmortem olfactory bulbs across limbic, early-neocortical, and neocortical LTS stages of parkinsonian patients, a proteostasis impairment, was observed, identifying 268 differentially expressed proteins betw ...[more]

PMID: 30342273

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