Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: Barbara Hofbauer
LAB HEAD: Stephan Axel Sieber
PROVIDER: PXD008067 | Pride | 2018-03-05
REPOSITORIES: Pride
Biochemistry 20180301 11
Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most potent compounds, AV73, not only reduced hemolytic alpha-hemolysin production in S. aureus but also impeded in vitro biofilm formation. ...[more]