Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle Fiber, Skeletal Muscle, Cell Culture
SUBMITTER: Janica Wiederstein
LAB HEAD: Marcus Krüger
PROVIDER: PXD008145 | Pride | 2018-05-04
REPOSITORIES: Pride
Wiederstein Janica Lea JL Nolte Hendrik H Günther Stefan S Piller Tanja T Baraldo Martina M Kostin Sawa S Bloch Wilhelm W Schindler Natalie N Sandri Marco M Blaauw Bert B Braun Thomas T Hölper Soraya S Krüger Marcus M
Cell reports 20180501 5
Protein aggregates and cytoplasmic vacuolization are major hallmarks of multisystem proteinopathies (MSPs) that lead to muscle weakness. Here, we identify METTL21C as a skeletal muscle-specific lysine methyltransferase. Insertion of a β-galactosidase cassette into the Mettl21c mouse locus revealed that METTL21C is specifically expressed in MYH7-positive skeletal muscle fibers. Ablation of the Mettl21c gene reduced endurance capacity and led to age-dependent accumulation of autophagic vacuoles in ...[more]