Proteomic profiles of INS1 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Rattus (black Rat)
TISSUE(S): Type B Pancreatic Cell
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: 
JUNJIE HOU
LAB HEAD: TAO XU
PROVIDER: PXD008154 | Pride | 2018-08-14
REPOSITORIES: Pride
Publications
Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.
Li Zonghong Z Liu Hongyang H Niu Zhangjing Z Zhong Wen W Xue Miaomiao M Wang Jifeng J Yang Fuquan F Zhou Yue Y Zhou Yifa Y Xu Tao T Hou Junjie J
Molecular & cellular proteomics : MCP 20180806 11
Chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. The underlying mechanisms, such as endoplasmic reticulum (ER) stress, oxidative stress and metabolic disorders, have been reported before; however, the time sequence of these molecular events is not fully understood. Here, using isobaric labeling-based mass spectrometry, we investigated the dynamic proteomes of INS-1 cells e ...[more]
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