Proteomics

Dataset Information

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Proteome analysis of Merkel cell carcinoma cell lines using SILAC


ABSTRACT: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin with growing incidence. In research immortalized cell lines are used for in vitro experiments in order to better understand the biology of this malignant disease.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Keratinocyte

DISEASE(S): Merkel Cell Carcinoma

SUBMITTER: Goran Mitulović  

LAB HEAD: Goran Mitulović

PROVIDER: PXD008181 | Pride | 2020-01-09

REPOSITORIES: Pride

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Publications

Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.

Kotowski Ulana U   Erović Boban M BM   Schnöll Julia J   Stanek Victoria V   Janik Stefan S   Steurer Martin M   Mitulović Goran G  

Clinical proteomics 20191219


<h4>Background</h4>Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin with growing incidence. To better understand the biology of this malignant disease, immortalized cell lines are used in research for in vitro experiments. However, a comprehensive quantitative proteome analysis of these cell lines has not been performed so far.<h4>Methods</h4>Stable isotope labelling by amino acids in cell culture (SILAC) was applied to six MCC cell lines (BroLi, MKL-1, MKL-2, PeTa,  ...[more]

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