Tyrosine-1 of RNA polymerase II CTD controls global termination of gene transcription in mammals
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ABSTRACT: The aim of the project was to analyse the functional role of Tyrosine-1 of mammalian RNA polymerase II CTD in the regulation of transcription-coupled processes. We studied mammalian CTD mutants to analyze the function of tyrosine1 residues. Mutation of 3/4 of the tyrosine residues in a mutant YFFF resulted in a massive read-through transcription phenotype. Read-through was observed for 3’ processed and polyadenylated RNAs. The YFFF mutant shows a loss of interaction with the Mediator and Integrator complexes in MS analysis.
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Ignasi Forne
LAB HEAD: Prof. Dr. Dirk Eick
PROVIDER: PXD008270 | Pride | 2018-01-09
REPOSITORIES: Pride
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